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KMID : 1144320170490010057
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감염과 화학요법
2017 Volume.49 No. 1 p.57 ~ p.61
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Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
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Park Jung-Yeon
Park Chul-Min
Chun Hye-Sun
Byun Ji-Hyun
Cho Sung-Yeon
Lee Dong-Gun
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Abstract
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Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensively reported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored according to the infection models and bacteria used. In this study, we infected 6-week-old female BALB/c mice intraperitoneally with different strains of resistant bacteria plus 3% hog gastric mucin. This method was found to be efficient and readily applicable for investigation of carbapenem-resisant Gram-negative pathogens (e.g., Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii) detected in Korea.
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KEYWORD
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Laboratory animal models, Peritonitis, Drug resistance, Multidrug resistance, Gram-negative bacteria
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